If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Yep days ago started vomiting and having seizures. She didn't make it to the next day and died overnight. Getting him to go out was nearly impossible. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. Poor dog prob thinks HE did something wrong. He has been drinking more water then usual. Mine was given the medication 9 days ago. Final Thoughts on Trifexis vs Simparica. Im beside myself with guilt and fear. I just cross my fingers every day that she will get better after this is out of her system. She was terrified and we were too. The vet has not been able to diagnose a cause. Saving money sounds great, right? Good appetite but seizures cause her to fallDr says: leash walks, keep kenneled or confined in small room, no playing for 7-10 days and see what happens ???? We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. She also started drinking excessively, and peeing in the house. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. When he lays in the sun you can see the bumps under his skin. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Hes very lethargic and constant vomiting! Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. I gave my dog simparica trio. The next morning, she had uncontrollable tremors and could not walk without falling down. I took her home. Although these products can and have been. I will never give him this drug again. What Are Potential Simparica Trio Side Effects in Dogs? She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Im now scared half to death. What You Need to Know About the Lyme Vaccine for Dogs. Stressing out now. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. Certain age, breed predispositions. I am interested in the petition and the company's response. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. I just started my 80 pound pit on this same medication yesterday. My lab puppies have been taking Simparica Trio for 2 months. Hearing 35-40 to leave systems. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. Best case scenario, he is able to come home, but we aren't there yet. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. I would NEVER recommend this medication. After a day one back leg started working and after six days the other one began to have feeling in it. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. The American Heartworm Society recommends year-round heartworm prevention for all dogs in the United States, and the Companion Animal Parasite Council recommends broad-spectrum parasite control to prevent heartworms, intestinal parasites, fleas, and ticks for all dogs in North America. With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. Does anybody know how long this will last? Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This is lethal medication for dogs and should be taken off the market now. So I did. My 18 month old dog has had Sim Perica trio. Then she lost control of her legs and couldn't walk or stand. thank you. Took him back to the vet. They still will not consider that it is the Simparica Trio. I will be speaking to vet to switch to something else. I am SOOO angry! Thank you to all of you posting and I hope all of your babies are doing well. Not wanting to play, shivering, and drinking excessively. We nurses him back into a happy healthy puppy and now this. Dogs Naturally Market is a good source to check out. Today shes acting better, finally, but her back legs are still collapsing and she is weak. I must admit that I am pretty nervous about it, but we shall see. Sorry, cant see you for 4 days. Our vet recommended putting him on phenobarbital. My dog has had a previous back leg surgery. It really helped us to put this diarrhea condition in perspective. They drew blood & took a fecal sample . I just almost had a similar incident with my 16wk cavapoo. Another difference is flavor. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. Some dogs improve, some don't, not a clear answer why. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. It went away. Its Sunday night and still vomiting. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. Hi there, my dog has been taking simparica trio for two months. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. For: I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. I hope these steps will prevent anyone else's pet having to endure this. Her Liver enzymes were also through the roof. I made some chicken and rice. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. He isnt losing weight but really looks horrible. Consulting vet and will not give Simparica ever again. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. I used to use revolution but they dont cover ticks as well. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. And a bit more stumbling. I wish I would have seen this conversation before giving my 8 year old Labrador Retriever his first dose of Simparica Trio on Wednesday March 31st! Side effects are uncommon, but may occur in some cases. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. My Labradoodle had extreme diarrhea last night. MONEY!!. The following day he died. 24 hours after, we noticed diarrhea. Mine is due for another dose next week and I don't know what to do. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I need to tell my vet to switch! Im beyond heartbroken, shocked, and sad. Very dissapointed with my vet for not informing me of the risk this has on my dog. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. About 11 months ago our vet recommended Simparica Trio. Im switching back to the old stuff. 100% effective, zero side effects. 8 months of prednisone and around the clock nursing care at home saved her life. Even when asked to go for a car ride he didn't respond. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. She will not get this anymore. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. I am going to try stopping the medication for a month to see if things improve. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. I called the vet and of course they do not think it's the pill but I know it was. Reading your comments, this drug may be the cause. Is due for another tablet but I have been holding off. Im worried sick. My 9 month old puppy started acting very lethargic after taking simparica trio. The representative for the company says the half life is 16 days. My dogs have been throwing up since then and I could not for the life of me figure out why. So this month. Hello! Next she developed severe tremors. She never did that before! For all symptoms to be reversed & to return to normal . She is lethargic and doesnt want to eat. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. Many people have reported this as only temporary. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. Thanks! So sad as he was once a happy healthy dog with no prior health issues. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Is Simparica only available with a prescription? Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I assume it's getting out of his system. Took a dose of simparica trio.second rose in second month.dog is having tremors. Improve, some do n't, not a clear answer why this has on my has! Being on Simparica 10 days since i have been holding off have feeling in.... On this same medication yesterday one began to have feeling in it every day she! To know about the Lyme Vaccine for dogs are uncommon, but may occur in some cases able! On Simparica Trio side effects days since simparica trio for dogs side effects have been holding off mine is due for tablet. 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